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Cyclosporine belongs to a group of drugs called immunosuppressants, which control the actions of the body’s immune system. Sometimes our immune system reacts excessively to abnormal cells and diseases or it attacks healthy tissue instead. This can happen after a recent organ transplant and could also lead to various autoimmune diseases, such as rheumatoid arthritis, psoriasis and Crohn’s Disease. Cyclosporine prevents the body from rejecting new organs after a transplant. Cyclosporine also effectively combats autoimmune diseases by suppressing unwanted reactions from the immune system.
Cipla Sold Under Brand Name:
Neoral, Sandimmune, Gengraf, Imusporin
Average Delivery Time:
How to use Cyclosporine should be taken orally, once or twice a day, at approximately the same time every day. You can take Cyclosporine with or without food but it is important to take this medication the same way each time. If you choose to take Cyclosporine with a meal, you should make sure to take every dose with the same type of food. Swallow the tablets whole and do not chew or crush them. It is equally important to take Cyclosporine at evenly spaced intervals to ensure there is a constant level of this medication in your blood stream at all times.
Your doctor will determine which dosage is best for you, depending on various factors, such as your height, weight, age, general health and the condition being treated.
Overdose Possible side effects of a Cyclosporine overdose include:
Pain in the upper stomach
Loss of appetite
Jaundice (yellowing of the skin or eyes)
Urinating less than usual or not at all
If you suspect you have taken too much of this medication, please contact your local poison control center or emergency medical services immediately.
Missed dose If you miss a dose of Cyclopsorine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not try to make up for a missed dose by doubling up.
Notes Your doctor may want to perform regular tests and medical check-ups to see how you are responding to Cyclosporine and if there are any unwanted side effects. You should also have your blood pressure regularly monitored.
Do not share this medication with others, as they may have a problem that is not effectively treated by this drug.
If you’ve recently had an organ transplant, it is highly recommended you attend a transplant education class or support group.
Storage Store Cyclosporine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), away from heat and moisture. KEEP THIS AND ALL OTHER MEDICATION OUT OF REACH OF CHILDREN.
Important note The above information is intended to supplement, not substitute for, the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed that the taking of this medication is safe, appropriate or effective for you.
* Illustrations are for graphic purposes only and the ordered medication may differ in appearance.
Precautions Before taking Cyclosporine, inform your doctor of your medical history, especially of:
A history of chickenpox or shingles
Uncontrolled high blood pressure
Skin lesions of unknown cause
Current use of radiation therapy (including phototherapy with PUVA or UVB)
Kidney or liver diseases
Any recent or current infections
Untreated mineral imbalance (e.g. low magnesium or high potassium)
Cyclosporine is classed as FDA Pregnancy Category C, which means it is not yet known if it can be harmful to an unborn baby. Inform your doctor immediately if you are pregnant or become pregnant during treatment with Cyclosporine. Do not use this medication while breastfeeding. Cyclosporine may pass into breast milk and could potentially harm a nursing infant. If you are breastfeeding and want to start treatment with Cyclosporine, contact your doctor immediately.
Cyclosporine may reduce the levels of magnesium in the blood stream. You should talk to your doctor about adding more magnesium to your diet.
Using Cyclosporine may cause swelling and growth of the gums (gingival hyperplasia). Brush your teeth and floss daily to minimize this problem and visit your dentist regularly.
Cyclosporine reduces the actions of your immune system and can therefore cause serious infections. Make sure you maintain a good personal hygiene while taking Cyclosporine.
Patients who take immunosuppressive medication in the long term are at increased risk of skin cancer. Avoid exposure to strong sunlight and wear a good sunscreen or protective clothing.
Drug Interactions Before taking Cyclosporine, you should inform your doctor if you take any of the following:
Birth control pills
Other immunosuppressants (e.g. Azathioprine, Methotrexate, Sirolimus)
Antibiotics including Tobramycin, Amphotericin B, Colchicine
Fibrates including Fenofibrate
NSAIDs including Diclofenac and Sulindac
Sulfa drugs including Sulfamethoxazole
Allopurinol, Amiodarone, Azole)
Antifungals (including Fluconazole and Ketoconazole)
Barbiturates including Phenobarbital, Bromocriptine
Calcium channel blockers including Diltiazem, Nicardipine and Verapamil
HIV protease inhibitors including Indinavir, Imatinib
Macrolide antibiotics including Erythromycin
Certain man-made male hormones such as Danazol and Methyltestosterone
Rifamycins including Rifampin
Certain anti-seizure drugs including Carbamazepine and Phenytoin
St. Johns wort
Certain Guinolones (Ciprofloxacin, Norfloxacin)
Other statins (Atorvastatin)
Drugs that may increase potassium levels (e.g. ACE inhibitors including Lisinopril, ARBs including Losartan, potassium supplements, diuretics including Amiloride and Spironolactone
The above is only a partial list and other medications may interact with Cyclosporine. Inform your doctor of all other prescription and over-the-counter medicines you use, including vitamins, nutritional supplements, herbal pills and medication prescribed by another doctor. Do not change medications without talking to your doctor first.
When taking Cyclosporine, you may notice any of the following common side effects:
Tremors or shaking
Increased hair growth
Headache or body pain
Diarrhea, constipation, vomiting
Numbness or tingly feeling
Swollen, red or painful gums
High blood pressure
Notify your doctor immediately if you experience any of these serious side effects:
Blurred vision, headache or pain behind your eyes, sometimes with vomiting
Muscle pain or weakness, fast heart rate, feeling light-headed
Signs of infection such as fever, chills, sore throat, flu symptoms
Pale skin, easy bruising or bleeding, unusual weakness
Nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
Fast or irregular heartbeat
Unusual weight loss or gain
Changes in the appearance of skin moles or lesions
Swollen glands or unusual lumps
Seek immediate medical help if you experience any of the following signs of an allergic reaction to Cyclosporine:
Swelling of the lips, face, tongue or throat
This is only a partial list of possible side effects and others may occur. Contact your healthcare provider immediately if any other side effects occur than the ones listed above or if they are especially bothersome.
How does Cyclosporine work?
Cyclosporine belongs to a group of drugs called immunosuppressants, which control the actions of the body’s immune system. Under normal circumstances, our immune system helps us fight diseases by recognizing and attacking pathogens and abnormal cells. However, sometimes the immune system reacts excessively to these threats or attacks healthy tissue instead. This can, for instance, happen after a recent organ transplant. It can also lead to a variety of autoimmune diseases. Cyclosporine works by slowing down the actions of the immune system, thus preventing the body from rejecting a transplanted organ. In the case of autoimmune diseases, Cyclosporine prevents the immune system from inflicting further damage on the body.
Are there any foods that interact with Cyclosporine?
Grapefruit and grapefruit juice can increase the amount of Cyclosporine in your blood stream and this can cause an increase in unwanted side effects. You should avoid eating grapefruit products or drinking grapefruit juice while taking Cyclosporine. Do not decrease or increase the amount of grapefruit products you consume without consulting your doctor first.
The recommended dosage of Cyclosporine to prevent transplant rejection is 14-18 mg per kg of body weight per day. The treatment should be started 4-12 hours before the operation and continued for 1-2 weeks after. After 1-2 weeks, your doctor may decide to reduce the dosage to 5-10 mg per kg of body weight per day.
For the treatment of rheumatoid arthritis and psoriasis, the recommended dosage of Cyclosporine is 2.5 mg per kg of body weight per day, divided into two doses per day. This dosage may gradually be increased to a maximum of 4 mg per kg of body weight per day.
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